The England defender was withdrawn at half-time from Manchester’s 6-3 Manchester derby at the Etihad with a muscle problem and did not take part in training, meaning he has been sidelined for the visit to Europe against Denmark.
Midfielder Rodri could return against Copenhagen, but Walker’s Three Lions team-mates John Stones and Kalvin Phillips remain sidelined.
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“We will train this afternoon and we will know exactly,” Pep Guardiola said in his pre-match press conference on Tuesday regarding the latest City squad news.
“Rodri is feeling better, but I think Kyle is out. But we have training later.”
Asked if Phillips could be available before the World Cup, Guardiola added: “I hope so. I hope for him and the national team. But I’m not a physio – the doctor told me he’s fine.
Ruben Dias was only fit for the bench against United, although there was some good news on the defensive front. Aymeric Laporte played his first minutes of the season after knee surgery in the summer, with both Nathan Ake and Manuel Akanji deputizing at centre-back.
Given City’s strong position in Group G, rotation could be in order, especially with a trip to Premier League Liverpool ahead.
Guardiola has already confirmed that Erling Haaland sometimes needs a rest and Wednesday’s game seems like the perfect opportunity.
Manchester City Predicted XI vs FC Copenhagen (4-3-3): Ederson; Cancelo, Akanji, Ake, Gomez; Gundogan, Silva, De Bruyne; Palmer, Alvarez, Grealish